A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives.
نویسندگان
چکیده
An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh2(OAc)4 and a chiral Brønsted acid was developed to efficiently produce β-hydroxy-α-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 26 شماره
صفحات -
تاریخ انتشار 2013